Association between bone mineral density and metabolic syndrome in Turkish women who were postmenopausal
Abstract
OBJECTIVE: To investigate the relationship between the parameters of metabolic syndrome and bone mineral density (BMD) at the femoral neck and lumbar spine in Turkish women who were postmenopausal.
METHODS: In a retrospective study, the records of patients who were postmenopausal attending the Menopause Outpatient Clinic of a tertiary women's hospital in Ankara, Turkey, between January 1, 2014 and December 31, 2014 were retrieved. Patient's BMD at the lumbar spine and femoral neck were assessed using T-scores, and parameters of metabolic syndrome were evaluated in all patients.
RESULTS: The records of 315 patients were retrieved. The mean age of patients was 55.63±6.14years (range 45-71 years). Metabolic syndrome was recorded in 92 (29.2%) patients. Following adjustment for age, patients with metabolic syndrome had higher T-scores at the femoral neck than patients without metabolic syndrome (-0.67±0.1 vs -1.15±0.06; P=0.001); there was no significant difference in T-scores at the lumbar spine (P=0.062). A Spearman correlation analysis of the entire study cohort demonstrated a negative association between high-density lipoprotein cholesterol and BMD at the lumbar spine and femoral neck (r=-0.12 and r=-0.15, respectively).
CONCLUSION: Metabolic syndrome could have been partly associated with increased BMD in Turkish women who were postmenopausal.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 315 participants or records.
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