Bone disease in patients with chronic kidney disease under conservative management
Abstract
CONTEXT AND OBJECTIVE: Few studies have focused on bone disease in patients with chronic kidney disease under conservative treatment. The objective was to evaluate bone disease in patients with chronic kidney disease.
DESIGN AND SETTING: Case series, at the Nephrology Division, Hospital Universitário Pedro Ernesto.
METHODS: 131 patients with creatinine clearance from 10 to 60 ml/min/1.73 m(2) were followed up for at least one year. Serum creatinine, albumin, calcium, phosphorus, alkaline phosphatase, total CO2 (tCO2), intact parathyroid hormone (iPTH), and alkaline phosphatase were measured. Creatinine clearance was calculated from 24-hour urine creatinine measurements and protein ingestion estimates from urea assays.
RESULTS: Patients presenting creatinine clearance 144 pg/ml showed osteitis fibrosa (4), mild lesion (4) and high turnover (1).
CONCLUSION: The present data suggest the importance of early control for iPTH and metabolic acidosis, among patients under conservative management for chronic kidney disease, in order to prevent complications related to bone disease.
CONTEXTO E OBJETIVO:: A doença óssea em pacientes com doença renal crônica sob tratamento conservador tem sido pouco estudada. O objetivo do estudo foi avaliar a doença óssea em pacientes com doença renal crônica.
TIPO DE ESTUDO E LOCAL:: Estudo de casos, na Disciplina de Nefrologia, Hospital Universitário Pedro Ernesto.
MÉTODOS:: Foram avaliados por pelo menos um ano 131 pacientes com clearance de…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 131 participants or records.
Read the paper
Related studies
- Development of a crushable foam model for human trabecular bone
- Data-driven motion compensation in HR-pQCT.
- Modeling of structure, quality, and function in the orthodontic patient
- Exploring the mechanism of Heidihuang Pill in the treatment of osteoporosis based on network pharmacology, molecular docking, and experimental validation
- Effect of fabric on the accuracy of computed tomography-based finite element analyses of the vertebra
- Use of interventions involving virtual reality tasks during the climacteric: a systematic review
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.