Effect of romosozumab in premenopausal women with severe osteoporosis and anorexia nervosa
Abstract
OBJECTIVES: This study aims to investigate the effects of romosozumab on bone mineral density (BMD) and bone metabolism.
METHODS: In this retrospective case series, romosozumab was administered to 5 premenopausal female patients with osteoporosis and anorexia nervosa with fragility fractures. BMD and bone turnover marker changes were investigated at 6 months and 1 year after administering romosozumab.
RESULTS: BMD increased and high-turnover bone metabolism decreased 6 months and 1 year after administering romosozumab.
CONCLUSIONS: Romosozumab is useful for treating osteoporosis in patients with anorexia nervosa.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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