Bone mineral density of lumbar vertebral end plates in the aging male sand rat spine
Abstract
STUDY DESIGN: Lumbar vertebral segments from young and old male sand rats were assessed for quantitative determination of lumbar end plate bone mineral density.
OBJECTIVES: To determine whether bone mineral density increases in the lumbar end plate with age in the male sand rat and to investigate its relationship to disc degeneration.
SUMMARY OF THE BACKGROUND DATA: Few basic science studies evaluated the end plate and disc degeneration. The sand rat provides an excellent economical model in which disc degeneration is reliable and well characterized.
METHODS: Bone mineral density data on cranial and caudal lumbar end plates of young (mean age 6.8 months) and old (mean age 23.3 months) male sand rats were assessed for changes related to age, lumbar position, and radiologic features.
RESULTS: Mean bone mineral density was significantly greater in end plates in older compared to younger males (P <or= 0.0018). Mean end plate bone mineral density within young animals was not significantly different in levels L5 to L7; in old animals, bone mineral density was significantly different (greater) progressing from L5 to L7 (P < 0.0001). In older animals, mean end plate bone mineral density for each disc showed a significant increase with lower lumbar sites (P = 0.0068). Mean end plate bone mineral density was significantly greater in animals with radiographic evidence of disc wedging (P = 0.006). End plate bone mineral density correlated positively with age.
CONCLUSIONS: Results…
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