Changes in autonomic balance of heart rate in male rats subjected to hypodynamia stress and gonadectomy
Abstract
OBJECTIVE: Aim: To analyze changes in variational cardiointervalometry indicators in male rats that have undergone castration and stress and their combination.
PATIENTS AND METHODS: Materials and Methods: The research was carried out on 48 white sexually mature rats, aged from 1.5 to 3.0 months, weighing from 180 to 200 g. All animals were divided into 4 experimental group: 1 - control, 2 - gonadectomy, 3 - stress, 4 - gonadectomy and stress. To study heart rate variability, the method of variational cardiointervalometry was used on "Cardiolab" (Kharkiv, Ukraine). ECG analysis imclude calculation of heart rate (HR, min-1); variational range of cardiac intervals (ΔX, s); mode (Mo, s); amplitude of mode (AMo, %); tension index (TI); index of autonomic balance; autonomiс rhythm index; indicator of adequacy of regulatory processes. ECG recording was performed under thiopental sodium anesthesia.
RESULTS: Results: Mo decreased in group 2 of rats, compared to 1, by 9.9 % (p<0.01). It was lower in group 3, compared to 1, by 11.2 % (p<0.001) and - group 4 - by 8.7 % (p<0.01). AMo decreased, compared to the control, only in group 3 by 22.4 % (p<0.001) and was lower compared to groups 2, and 4. The lowest ΔX values were observed in group 2 of rats. HR increased in group 2 of rats, compared to group 1, by 11.0 % (p<0.001), in group 3 of rats, compared to group 1, by 12.7 % (p<0.001) and was higher in this group, compared to group 4, by 8.0 % (p<0.01). Increase in the TІ was noted in…
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