Abstracts from The XXV Brazilian Diabetes Society Meeting
Abstract
Introduction: Type 1 diabetes (T1DM) is a well-established risk factor for chronic kidney disease (CKD), typically manifesting as diabetic kidney disease (DKD).CKD severity is classified by the KDIGO guidelines, which combine glomerular filtration rate (GFR) and albuminuria categories.Objective: To assess CKD occurrence and staging in individuals with T1DM, correlating kidney function with clinical factors, and evaluating the influence of gender, insulin regimen, and diabetic ketoacidosis (DKA) at disease onset on renal outcomes.Methods: An observational, retrospective study analyzing data from 530 patients with T1DM followed at a single university hospital between January 2014 and June 2025.CKD staging was determined based on GFR and albuminuria, and its association with clinical parameters was evaluated.Results: The cohort included 298 women (56.2%) and 232 men (43.8%), with a median age of 28 years (interquartile range [IQR]: 22-36).Reduced GFR (stage G3a or worse) was identified in 57 patients (10.8%), while albuminuria (A2 or worse) was present in 164 patients (30.9%).Among 295 patients with available data, 147 (49.8%) had a history of DKA at disease onset.GFR declined by an average of 1.9 per year of disease duration in men and 1.2 in women (p = 0.02).Additionally, each additional year of age at diagnosis was associated with a GFR reduction of 2.3 in men and 1.1 in women.The regression model explained 41.4% of GFR variance in men (R 2 = 0.41) and 20.4% in women (R 2 =…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 530 participants or records.
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