Outcomes following structural allograft-chain impaction kyphoplasty
Abstract
Background: Kyphoplasty (KP) commonly uses bone cement to augment vertebral bodies and to reduce pain after a compression fracture or vertebral collapse. However, cement may pose risk of extravasation and potentially compromise future operations on the injured vertebral body. Impaction grafting with allografts is a commonly used orthopedic technique to support weak bones, fill bone voids, and restore normal bone within a region. The goal of this study is to evaluate height restoration, pain relief, and extravasation in a 1-year follow-up of patients who underwent impaction grafting kyphoplasty with allograft.
Methods: Patients underwent impaction grafting kyphoplasty procedures either with or without an initial cavity. Preoperative and 1-year postoperative MRI and CT images were used to determine vertebral height (corrected for adjacent vertebrae) and incidence of adjacent vertebral fractures. In addition, pain relief using the NRS was measured over the 6-month postoperative period. Incidence of extravasation and presence of a radiolucent halo were measured for each vertebra 1-year postoperatively. The unit of analysis for clinical outcomes was the patient and for radiological outcomes was the vertebra. Paired t-tests were used to compare pre- and postoperative vertebral heights and NRS pain scores.
Results: Vertebral body height was maintained (>0 mm change) in 41 (51%) of 80 vertebrae, and 28 (35%) increased more than 1 mm. The average increase for 80 vertebral bodies was…
Read the paper
Related studies
- A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
- A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin
- Cancer epigenetics: Moving forward
- Current developments in LC-MS for pharmaceutical analysis
- Myricetin: A comprehensive review on its biological potentials
- A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.