Studies on Drug Delivery Efficacy of Silver Nanoparticles Synthesized using Human Serum Albumin as Tamoxifen Carriers in MCF-7 Cell Line
Abstract
Tamoxifen (Tam) has a broad spectrum of anticancer activity, but is limited in clinical application.The aim of this study was to explore the smart pH-responsive drug delivery system based on Human Serum Albumin (HSA) reduced Silver nanoparticles (AgNps)for its potential in enabling more intelligent controlled release and enhancing chemotherapeutic efficiency of tamoxifen.Tamoxifen was loaded onto HSA reduced AgNps by forming complexes and Tamoxifen was released from the drug delivery system much more rapidly at pH 4.0 and 6.0 than at pH 7.4, which is a desirable characteristic for tumor targeted drug delivery.Tamoxifen loaded HSA reduced AgNps induced remarkable improvement in anticancer activity a demonstrated by MTT assay and AO/EtBr staining and the results indicated that the drug loaded nanoparticles could act as an efficient drug delivery system which import Tamoxifen into target cancer cells.
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