Formulation And Evaluation Of Fast Dissolving Tamoxifen Citrate Tablet For Breast Cancer
Abstract
This study investigates the formulation and evaluation of fast dissolving tablets of Tamoxifen citrate, a crucial drug in breast cancer therapy, aimed at enhancing solubility and bioavailability. The formulation process involved the selection of suitable excipients to improve the solubilization of Tamoxifen citrate, ultimately leading to enhanced dissolution properties. Solubility studies indicated a significant increase in the drug's availability, enabling faster therapeutic action. Fourier Transform Infrared (FTIR) analysis confirmed the compatibility of the drug with the excipients, ensuring that the drug’s chemical integrity was maintained throughout the formulation. Comprehensive pre- and post-compression studies revealed that the powder blend exhibited acceptable flow and compressibility, resulting in tablets characterized by appropriate hardness, weight uniformity, and negligible friability. Disintegration tests demonstrated that the tablets disintegrated rapidly, highlighting their potential for immediate release in the oral cavity, which is particularly beneficial for patients with swallowing difficulties. Subsequent dissolution studies showcased a robust release profile, with a substantial amount of Tamoxifen citrate being released within a short time frame. Kinetic analysis of the dissolution data indicated that the release mechanism followed zero-order kinetics, suggesting a consistent release rate independent of the concentration remaining in the tablet…
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