The effect of Cornus mas L. fruit extract supplementation on glycemic control, insulin resistance, and adiponectin levels in patients with metabolic dysfunction-associated steatotic liver disease: a double-blind randomized controlled clinical trial
Abstract
Background: Available evidence regarding effect of Cornus mas L. fruit extract (CMFE) as an anthocyanins source on glycemic control, insulin resistance, and adiponectin levels among metabolic dysfunction-associated steatotic liver disease (MASLD) patients is limited and controversial. Thus, this study aimed to assess effect of CMFE on glycemic control, insulin resistance, and adiponectin levels in MASLD patients.
Methods: This double-blind, randomized controlled clinical trial was carried out among 50 MASLD patients for 12 weeks. The participants were randomly categorized into the CMFE (CMFE, 20 cc/day; providing 32 mg/day total anthocyanin) or the placebo groups. Fasting plasma glucose and insulin levels, adiponectin, homeostatic model assessment of insulin resistance, triglyceride and glucose index, metabolic score for insulin resistance, quantitative insulin sensitivity check index, and visceral adiposity index were evaluated at baseline and after 12 weeks. Finally, a total number of 40 individuals completed the study (CMFE group: n = 18, placebo group: n = 22).
Results: Adiponectin levels significantly reduced after 12 weeks versus baseline in the placebo group among total population (ITT approach: baseline: 610.0 (430.0 to 710.0), after 12 weeks: 460.0 (390.0 to 580.0); P = 0.01) and among women (ITT approach: baseline: 675.0 (605.0 to 742.50), after 12 weeks: 435.0 (417.5 to 582.50), P = 0.01) without any significant difference in compared with the CMFE group.…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 50 participants or records.
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