A Comprehensive Review On Analytical Methods-For The Quantification Of Empagliflozin In Drug Product And Drug Substance
Abstract
Pharmaceutical analysis plays an important role in the quantification of drugs in pharmaceutical products and it employs a significant role in the analytical research and development and in quality control of finished products and drug substances and also in the bio analytical method development. Empagliflozin, a new oral anti-diabetic drug which is used to treat the type 2 diabetes and it is a selective sodium- glucose co transport–2[SGLT2] inhibitor by inhibiting the reabsorption of glucose from proximal tubules of the kidney and excretes as such through urine by SGLT-2 receptor inhibition. The main advantage of this gliflozin category is that they will improve the functioning of heart and kidneys of the patients who suffering from cardiovascular disease and chronic kidney diseases (CKD). Empagliflozin is available in tablet dosage forms with the strength of 10mg and 25mg. The current review article will provide the analytical data for the quantification of Empagliflozin in various pharmaceutical formulations and in biological samples by using different analytical methods like HPLC, UHPLC, LC MS/MS and UV- Visible Spectrophotometric methods.
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