Comparing Appetite and Dietary Intake Responses to Resistance Exercise in Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy Versus Individuals Without Cancer: A Secondary Analysis
Abstract
Breast cancer survivors (BCS) undergoing adjuvant endocrine therapy have increased risk of obesity. Estrogen and exercise suppress appetite in non-BCS populations, but their combined effects in BCS are unknown. This secondary analysis compared the impact of acute resistance exercise (REx) on appetite and energy intake in estrogen-suppressed BCS versus females without cancer ('non-BCS'). Premenopausal inactive BCS (stage 0-III estrogen receptor-positive breast cancer, 2) and 12 non-BCS (age: 37 ± 8; BMI: 29.0 ± 5.1 kg/m2) were included. BCS showed greater PYY 90 and 120 min post-breakfast compared to non-BCS, particularly after REx (group x time x condition: p = 0.009, p = 0.005, respectively). No group effects were observed for ghrelin. BCS had lower body mass-adjusted energy intake compared to non-BCS (p = 0.036), despite similar appetite ratings. Estrogen-suppressed BCS exhibit heightened PYY and lower energy intake after REx, revealing novel effects of exercise on appetite in a state of low estrogen.
How strong is the evidence?
Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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