Targeting metabolic dysregulation in postmenopausal breast cancer: Synergistic effects of nutrition-based interventions and exercise on molecular and cellular pathways
Abstract
Postmenopausal females diagnosed with breast cancer who are undergoing aromatase inhibitor (AI) therapy often exhibit metabolic disturbances, which may manifest as insulin resistance, dyslipidemia, increased adiposity, and an elevated risk of cardiovascular events. Such metabolic disruptions have the potential to undermine the efficacy of treatment and intensify therapy-related adverse effects, thereby diminishing overall quality of life. The implementation of functional nutrition and exercise-based interventions has emerged as a viable adjunctive therapeutic strategy aimed at addressing these metabolic complications by influencing fundamental mechanistic pathways, including chronic inflammation, oxidative stress, hormonal imbalances, and mitochondrial dysfunction. This review systematically investigates the phenomenon of metabolic dysregulation within this specific patient demographic and emphasizes the impact of particular dietary constituents in conjunction with organized aerobic and resistance training on critical metabolic regulators, including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptors, and insulin signaling cascades. The therapeutic efficacy associated with the incorporation of these lifestyle modifications is examined within the framework of optimizing glucose homeostasis, lipid profiles, and attenuating systemic inflammation. Comprehending these mechanistic pathways establishes a basis for the formulation of personalized…
Read the paper
Related studies
- A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
- A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin
- Cancer epigenetics: Moving forward
- Current developments in LC-MS for pharmaceutical analysis
- Myricetin: A comprehensive review on its biological potentials
- A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.