Skeletal adaptations during growth
Abstract
The authors examine the role of mechanical usage in skeletal development. Principle mechanisms of bone physiology include longitudinal bone growth; modeling drifts; micromodeling; remodeling by the basic multicellular unit and its effects on bone mass, bone turnover, and bone gain or loss; setpoint effects; microdamage and its repair; and the effects of mechanical usage. Biomechanical explanations for the architecture of growing long bones are examined. Clinical problems that involve principal biological mechanisms include osteopenia; influence of hormones, cytokines, drugs, other agents, and setpoints; osteoporosis and bone fragility; stress fractures; homeostasis and calcium; and fracture healing.
Read the paper
Related studies
- Benign periarticular, bone and joint lipomatous lesions
- A review of the physiological and histological effects of laser osteotomy
- Quality of bone healing: perspectives and assessment techniques
- Effects of bioactive lipids and lipoproteins on bone
- Bone structure and function
- Quantifying bone structure, micro-architecture, and pathophysiology with MRI.
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.