Roles of Goserelin in Gynecological Disorders
Abstract
Goserelin is a gonadotropin-releasing hormone (GnRH) agonist with a long history of clinical application and well-established efficacy and safety profile. Its mechanism of action centers on sustained GnRH receptor desensitization, leading to pituitary downregulation, ovarian suppression, and reduction of estradiol and progesterone to postmenopausal levels; this forms the basis for its efficacy in hormone-dependent gynecological conditions. Over the past three decades, the use of goserelin has been expanded to an increasing number of indications and clinical scenarios. Approved gynecological indications of goserelin include endometriosis, uterine fibroids, usage as an agent for endometrial thinning, and usage as an agent for ovarian downregulation prior to assisted reproduction. More recent research continues to explore the use of goserelin in gynecological diseases such as adenomyosis and different types of female cancers. Goserelin may also be a useful tool in clinical scenarios where gynecologic management is required as part of multi-disciplinary therapy. This review consolidates the established and emerging roles of goserelin across the broad spectrum of benign and malignant gynecological conditions, underscoring its remarkable clinical versatility and the breadth of evidence that support its continued expansion of utility in contemporary practice.
Read the paper
Related studies
- A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
- A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin
- Cancer epigenetics: Moving forward
- Current developments in LC-MS for pharmaceutical analysis
- Myricetin: A comprehensive review on its biological potentials
- A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.