Analysis of the timing of puberty in a recent cohort of Italian girls: Evidence for earlier onset compared to previous studies
Abstract
BACKGROUND
throughout the twentieth century, in developed countries there has been a secular trend towards earlier menarche. Over the last two decades, however, there has been an apparent stabilization in the average age of menarche age in most Western countries.
OBJECTIVES
to analyze the mean age of menarche in a cohort of Italian girls; to analyze the mean age of breast button appearance (B2); to correlate the B2 developmental stage and age at menarche with the most important clinical and auxological parameters.
PATIENTS AND METHODS
we retrospectively evaluated the data of 1458 Italian girls, born between 1995 and 2003. We collected the main auxological and clinical parameters, including age at B2, age at menarche, height, weight and BMI at B2 and menarche and, when possible, adult/near adult height.
RESULTS
the mean age of B2 was 10.16 ± 1.00 years, significantly early than previously reported for Italian girls (p<0.05); the mean age of menarche was 12.07 ± 0.99 years, also significantly earlier than previously reported (p<0.0001). Age at B2 and menarche inversely correlated with BMI SDS (p <0.0001). The mean adult/near adult height of the girls in the study cohort was not statistically different from previously reported data for Italian women.
CONCLUSIONS
our results suggest a new trend for an earlier appearance of thelarche and menarche in Italian girls. Our data confirm a significant relationship between BMI and age of B2 and menarche. The girls' final height seems to…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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