P291 Evaluating the impact of educational material on anastrozole treatment adherence – the baseline results of the ARTEMIS study
Abstract
Goals:We performed a meta-analysis of three randomised sub-studies of the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial to determine the effects of exemestane and tamoxifen on bone health.Methods: Patients received exemestane or tamoxifen as adjuvant therapy for hormone receptor-positive breast cancer.Bone mineral density (BMD) was assessed at baseline and after 12 and 24 months of treatment.Bone turnover markers were also measured.Results: Patients receiving tamoxifen showed a mean increase from baseline in lumbar spine BMD of 1.2% at month 12 and 0.2% at month 24.Patients receiving exemestane showed a mean decrease from baseline of 2.6% after 12 months and 3.5% after 24 months.There were significant differences in the changes in lumbar spine BMD between treatment groups (P < 0.0001 at both time points).Changes in BMD from baseline at the total hip were also significantly different between exemestane and tamoxifen (P < 0.05 at both time points).Bone turnover markers decreased from baseline with tamoxifen and increased with exemestane.Conclusion: Exemestane resulted in decreases in BMD and increases in bone turnover markers.BMD increased and bone turnover markers decreased with tamoxifen.
How strong is the evidence?
Evidence Hub reads this as a randomized trial. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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