Strategies for the Selection and Application of Biological Scaffolds in Organ-on-a-Chip Systems
Abstract
As an emerging microphysiological system, organ-on-a-chip (OoC) replicates human organ structures and functions through microfabrication, holding promise as novel platforms for drug screening, disease modeling, and toxicity testing, although their broad application still faces significant validation challenges. This review systematically examines biomimetic scaffold selection strategies in OoC systems, with a focus on hydrogels, hydrogel microspheres, and other scaffold types. It details chip fabrication processes, including design concepts, material selection, microfabrication technology, and cell sources. By comparing physicochemical properties, biocompatibility, and functional characteristics of different materials, this paper explores optimal scaffold strategies for specific organ simulations. Based on comprehensive analysis, hydrogel scaffolds have become widely adopted for OoC construction due to their excellent biocompatibility and extracellular matrix-like properties. Synthetic polymers and bioceramic scaffolds demonstrate significant value in meeting specific mechanical requirements and constructing complex microstructures. As a novel hydrogel form, hydrogel microspheres exhibit considerable potential in dynamic culture simulation and drug delivery owing to their high specific surface area and controllable release capabilities. This paper also discusses future directions, including personalized scaffold design, intelligent responsive materials, and multiorgan…
Read the paper
Related studies
- A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
- A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin
- Cancer epigenetics: Moving forward
- Current developments in LC-MS for pharmaceutical analysis
- Myricetin: A comprehensive review on its biological potentials
- A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.