Objective Assessment of Physical Activity in Breast Cancer Survivors: Associations With Adiposity and Metabolic Parameters of Glucose and Insulin-Insights From NHANES
Abstract
Background: Physical activity (PA) is a modifiable lifestyle factor strongly linked to adiposity and metabolic health. Breast cancer survivors are at a higher risk of obesity-related metabolic complications, negatively impacting prognosis and quality of life. Therefore, updated objective assessments of PA and its effects on metabolic health are critical to improving survivorship care.
Aims: To analyze the most recent nationally representative sample of the US population where physical activity was objectively measured to identify associations between PA, adiposity measures, and metabolic health parameters among cancer survivors, specifically breast cancer survivors.
Methods and results: NHANES data from 2011 to 2014 is used to examine associations between PA, adiposity measures, and metabolic parameters in women aged 20 and older. PA is objectively measured using accelerometer data. Adiposity is assessed via sagittal abdominal diameter (SAD), waist circumference (WC), and body mass index (BMI), and the metabolic parameters are glucose and insulin. The analysis involved regressing the natural logarithms of SAD, WC, BMI, glucose, and insulin on moderate-to-vigorous and sedentary PA levels. The sample consisted of 4068 participants, including 397 with cancer diagnoses and 118 with breast cancer. Additionally, factors such as ethnicity, education, income, age, energy intake, diabetes, and smoking habits were considered. The associations between adiposity measures and excess…
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