Evaluation of the severity of right to left shunt in patent foramen ovale patients after systemic embolism (MEASURE-PFO study)
Abstract
BACKGROUND
Patent foramen ovale (PFO) is the most common inherited cardiac abnormality, with intermittent right-to-left (R-L) shunt of variable size.
AIMS
To study the quantification of R-L shunt (shunt) in PFO patients using an original thermodilution method in relationship to the morphology of the interatrial septum, measured by echocardiography and cardiopulmonary exercise tests before and after the occlusion of a PFO.
RESULTS
A multicenter study enrolled a population of 151 patients, eligible for PFO closure in secondary prevention, underwent transthoracic echocardiography and contrast transesophageal echocardiography, cardiopulmonary exercise tests before and 6 months after the closure. The size of the shunt was measured by catheterization using the thermodilution Inntherm® system. Shunt was detected in 133 (90%) patients. Size of shunt >20% was present in 41 (28%) patients, 10%-20% in 33 (22%), and 10% was associated with greater atrial septal separation during the Valsalva (P = 0.03) and respiration (P = 0.04), amplitude of septal displacement (P = 0.009), amount of contrast media in the left atrium (LA) (P = 0.03) and hypermobility of septum (P = 0.03). After PFO closure, work capacity increased in patients with shunt ≥20% (Δ +6.8; standard deviation [SD] 16.9 [W]) compared with those with <10% (Δ -2.1; SD 24.5 [W]; P = 0.02). Migraine occurrence decreased in 8 patients (62%) (P = 0.008). A decrease in saturation on exercise occurred in 12 cases (9%), after the PFO…
Read the paper
Related studies
- A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker
- A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin
- Cancer epigenetics: Moving forward
- Current developments in LC-MS for pharmaceutical analysis
- Myricetin: A comprehensive review on its biological potentials
- A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.