Pressure Natriuresis in Blood Pressure Control
Abstract
The kidneys play an important role in controlling arterial blood pressure by regulating extracellular fluid volume, through excretion of sodium and water, which is called pressure natriuresis, or diuresis. Sodium and water homeostasis is controlled by the integrated physiological functions of organ systems, including renal mechanisms, but also with an influence of the renal and non-renal sympathetic nervous system and the endocrine system (renin-angiotensin-aldosterone system, cardiac natriuretic peptides, antidiuretic hormone, and oxytocin). Pressure natriuresis represents the basal level for arterial blood pressure dysregulation. The imbalance of complex renal and non-renal hemodynamic and neurohumoral mechanisms leads to the disruption of antidiuretic mechanisms, which results in the development of arterial hypertension. Knowledge of all mechanisms enables an integrated understanding of the regulation of arterial blood pressure, which is a key step in the targeted and individual treatment of one of the most common diseases today.
Read the paper
Related studies
- Strategy for Mitigating DKA Risk in Patients with Type 1 Diabetes on Adjunctive Treatment with SGLT Inhibitors: A STICH Protocol
- Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance
- SGLT2 Inhibitors in Heart Failure: Targeted Metabolomics and Energetic Metabolism
- Mechanisms of blood pressure reduction with sodium-glucose co-transporter 2 (SGLT2) inhibitors
- Sodium-glucose cotransporter inhibitors: beyond glycaemic control
- Decoding the effects of SGLT2 inhibitors on cardiac arrhythmias in heart failure
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.