Cardiac Energy Metabolism and the Role of SGLT2 Inhibitors in Heart Failure
Abstract
Heart failure (HF) is a condition where the cardiac muscle exhibits contractile dysfunction, limiting its ability to deliver adequate amounts of oxygen to organs throughout the body. Despite improved survival seen with pharmacological and mechanical treatment strategies, HF patients continue to experience high hospitalization and mortality rates, resulting in poor quality of life and a significant burden on healthcare. As such, the need for better therapies for HF has helped expand our understanding of the development and progression of the disease, including the role that metabolic perturbances may play. Particularly, it is becoming more evident that cardiac substrate metabolism is impaired at the transcriptional level of metabolic enzymes, playing an important role in HF pathogenesis. Researchers, therefore, believe that therapeutic approaches designed to optimize cardiac energy production may be beneficial in the treatment and management of clinical HF. However, whether or not this loss of metabolic flexibility in the failing heart is permanent and thus cannot be corrected by interventions remains unclear. In addition, the sodium/glucose cotransporter (SGLT) 2 inhibitor, empagliflozin, has been shown to profoundly reduce cardiovascular mortality and HF hospitalization in diabetic patients with high-risk of cardiovascular disease. Of importance, empagliflozin is thought to exert cardiovascular benefit upon improving substrate availability and myocardial energetics, and…
Read the paper
Related studies
- Strategy for Mitigating DKA Risk in Patients with Type 1 Diabetes on Adjunctive Treatment with SGLT Inhibitors: A STICH Protocol
- Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance
- SGLT2 Inhibitors in Heart Failure: Targeted Metabolomics and Energetic Metabolism
- Mechanisms of blood pressure reduction with sodium-glucose co-transporter 2 (SGLT2) inhibitors
- Sodium-glucose cotransporter inhibitors: beyond glycaemic control
- Decoding the effects of SGLT2 inhibitors on cardiac arrhythmias in heart failure
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.