Modulation of MicroRNAs Linked to Pain-migraine by Ketogenic Diet (P14-007-19)
Abstract
Migraine is a neurovascular disorder with complex pathophysiology. The ketogenic diet (KD) it is well recognized to treat epilepsy drug-resistant as well as other neurological disorder including migraine. Our previous study showed that six weeks of biphasic KD influences circulating microRNAs (miRs) linked to energy metabolism (Cannataro R., Perri M. et al. MicroRNA (2019) 8: 1). At the end of the study, six female obese patients self-reported to had a better outcome of pain-migraine and migraine attack. Therefore, we analyzed miRs associated with pain-migraine. The KD was planned depending on the dietary diary recorded by each subject for 14 days before starting the KD program and was set with less than 30 g of carbohydrate per day. Six female obese patients in stage 1 of the Edmonton Obesity Staging System (EOSS) parameter self-reporting suffering of migraine were analyzed for miRs linked to pain-migraine. 200 microL of blood/serum was used for the extraction of miRs and their expression profile was achieved by direct hybridization using the multiplexed NanoString nCounter-flex system. In silico bioinformatics approach (using miRWalk, miR target link, and target scan) were employed to detect target genes and miRNA-regulated biological function. The six female obese patients whose reduce their weight during the biphasic KD program, self-reported that migraines attack disappeared only during, and not outside, the cycles of biphasic KD program. Among the 7 miRs linked to…
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