Diabetes-related renal complications: Insights on the impact of diabetic kidney disease on mortality
Abstract
Diabetes mellitus (DM) is a major contributor to disability and mortality, accounting for nearly 10% of all deaths in people aged 20 to 79 years. In addition, the increasing prevalence of diabetes has significantly increased the burden of disease across multiple facets of the disease spectrum. Diabetic kidney disease (DKD) is an important factor affecting morbidity and mortality in people with diabetes. DKD is characterized by a gradual deterioration of kidney function leading to end-stage renal disease (ESRD) in up to 50% of cases in certain populations and increased susceptibility to cardiovascular events. DKD is generally characterized by chronic kidney disease (CKD) defined by persistently (at least 3 months) elevated urinary albumin excretion (albumin-to-creatinine ratio ≥ 30 mg/g) and/or decreased estimated glomerular filtration rate (estimated glomerular filtration rate < 60 mL/minute/1.73 m²) in people with diabetes. As glomerular filtration rate decreases and albuminuria increases, the likelihood of adverse outcomes such as mortality and ESRD increases. People with a GFR ≤ 30 mL/minute/1.73 m² have a significantly increased risk in all categories of albuminuria. It is of pivotal importance to understand the pathophysiology of DKD, its gradual progression and the significant impact on mortality in diabetic patients. Early detection and optimal glycemic and blood pressure control are crucial to counteract the progression of the disease. Another important aspect is to…
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.