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Safety and efficacy of COVID‐19 vaccines: A systematic review and meta‐analysis of controlled and randomized clinical trials

Jayesh V. Beladiya, Anup Kumar, Yogesh Vasava, Krupanshu Parmar, Dipanshi Patel, Sandip Patel, Sandip P. Dholakia, D. Sheth et al.

Reviews in Medical Virology, 2023

247,186 participants · 100 citations

Abstract

Vaccines against coronavirus disease 2019 (COVID‐19) have been discovered within a very small duration of time as compared to the traditional way for the development of vaccines, which raised the question about the safety and efficacy of the approved vaccines. The purpose of this study is to look at the effectiveness and safety of vaccine platforms against the incidence of COVID‐19. The literature search was performed on PubMed/Medline, Cochrane, and clinical trials.gov databases for studies published between 1 January 2020 and 19 February 2022. Preferred Reporting Items for Systemic Review and Meta‐Analysis Statement guidelines were followed. Among 284 articles received by keywords, a total of 11 studies were eligible according to the inclusion and exclusion criteria (studies in special populations, e.g., pregnant women, paediatric patients, editorials, case reports, review articles, preclinical and in vitro studies) of the study. A total of 247,186 participants were considered for randomisation at baseline, among them, 129,572 (52.42%) were provided with vaccine (Intervention group) and 117,614 (47.58%) with the placebo (Control group). A pooled fold change estimation of 0.19 (95% CI: 0.12–0.31, p < 0.0001) showed significant protection against the incidence of COVID‐19 in the vaccines received group versus the placebo group. mRNA based, inactivated vaccines and non‐replicating viral vector‐based vaccines showed significantly protection against the incidence of COVID‐19…

How strong is the evidence?

Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 247,186 participants or records.

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