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Resistance to Levofloxacin and Failure of Treatment of Pneumococcal Pneumonia

Ross Davidson, Rodrigo Brandao Cavalcanti, JAMES L. BRUNTON, Darrin J. Bast, Joyce C. S. de Azavedo, Pamela Kibsey, Christine Ann Fleming, Donald E. Low

New England Journal of Medicine, 2002

539 citations

Abstract

This report describes four patients with pneumococcal pneumonia in whom empirical treatment with levofloxacin failed. In these patients, the isolates of Streptococcus pneumoniae were resistant to levofloxacin, and in two of them the resistance appeared to have been acquired during the current course of treatment with fluoroquinolones.

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