Diamonds in the Rough
Abstract
Diamonds in the Rough The Incredible-but-True Story of Sodium Glucose Cotransporter 2 Inhibitors in Treatment of Heart FailureArticle, see p 337 A n old story describes a farmer who led a contented life until he found out about the existence of precious stones.He became so fascinated with diamonds, that he traveled around the world, spending all his resources in hopes of finding them, but only leading to disappointment.Despondent and disillusioned, with all hope and money lost, he returned to his farm only to find out that while he was traveling, something interesting happened on his property.While taking a camel to a nearby brook, someone noticed a rock glinting in the sunlight.The person picked it up and placed it in the farmer's house.On returning, the farmer immediately recognized the object as a large diamond in the rough.It turned out, that his very farm was sitting on the mine of Golconda -one of the most splendid diamond mines ever discovered.The moral of the story is that one does not need to travel far to make magnificent discoveries; they may be right under your nose, hiding in plain sight.A similar sentiment is invoked when one reflects on the amazing journey of sodium glucose cotransporter 2 (SGLT2) inhibitors, from agents destined to be just one of many glucose-lowering drugs, to their emergence as foundational pillars in the treatment of patients with heart failure (HF).Because of their mechanism of action, blocking glucose (and sodium) reabsorption in the…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 4,744 participants or records.
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