Is metformin a possible treatment for diabetic neuropathy?
Abstract
Metformin is a hypoglycemic drug widely used in the treatment of type 2 diabetes. It has been proven to have analgesic and neuroprotective effects. Metformin can reverse pain in rodents, such as diabetic neuropathic pain, neuropathic pain caused by chemotherapy drugs, inflammatory pain and pain caused by surgical incision. In clinical use, however, metformin is associated with reduced plasma vitamin B12 levels, which can further neuropathy. In rodent diabetes models, metformin plays a neuroprotective and analgesic role by activating adenosine monophosphate-activated protein kinase, clearing methylgloxal, reducing insulin resistance, and neuroinflammation. This paper also summarized the neurological adverse reactions of metformin in diabetic patients. In addition, whether metformin has sexual dimorphism needs further study.
二甲双胍是一种广泛用于治疗2型糖尿病的降糖药物。它已被证明具有镇痛和神经保护作用。二甲双胍可以逆转啮齿类动物的疼痛，如糖尿病性神经痛、化疗药物引起的神经性疼痛、炎症性疼痛、手术切口引起的疼痛。然而，在临床使用中，二甲双胍与血浆维生素B12水平降低有关，这可能会进一步加剧神经病变。在啮齿动物糖尿病模型中，二甲双胍通过激活AMPK、清除MGO、降低胰岛素抵抗和神经炎症发挥神经保护和镇痛作用。本文还总结了二甲双胍对糖尿病患者的神经系统不良反应。此外，二甲双胍是否有两性区别还有待进一步研究。.
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.