Inhibitory effect of metformin on the development of cholesterol atherosclerosis in the rabbit. Observations on the coronary vessels
Abstract
Experimental atherosclerosis and atheroregression may appear at different levels of development in the different arterial districts of non-human primates. The coronary arteries that are involved, like aortas, in the atherogenic process are, in the monkeys, less prone to atheroregression. The atherosclerotic lesions which are always present in the coronary arteries of the hypercholesterolemic rabbits are not evident in the coronaries (at extra- as well at intracardiac level) of the hypercholesterolemic rabbits treated with metformin.
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.