An in silico Modeling for the Prediction of Metformin Interaction with Gadolinium-Based MR Contrast Agent
Abstract
Background and Objective:The continued use of metformin with magnevist, a gadolinium-based MR imaging contrast agent, has been demonstrated to likely exhibit effects of antagonism and synergism.Metformin, a common drug used for the treatment of diabetes mellitus, works to lower glucose concentration in the blood and plasma.There has been a lack of consensus regarding its cessation and resumption in patients advised to undergo contrast-enhanced examinations.This predictive study was performed to elucidate the underlying drug-drug interactions (DDI) of metformin with magnevist in patients undergoing contrast-based imaging examinations. Materials and Methods:The possible effects of combined administration of metformin and magnevist were investigated by ChemDIS-Mixture (v.5.0, medium confidence score 0.4).The significance level for the analysis was set at 0.05, with Benjamini-Hochberg multiple test correction.Results: The results of the study demonstrated various proteins, gene ontology (GO), disease ontology (DO) and DOLite terms to be in common with both metformin and magnevist.The study findings revealed one GO term denoting signalling pathway (cysteine-type endopeptidase activity), five DO terms (opportunistic mycosis, essential tremor, sudden infant death syndrome, severe combined immunodeficiency and combined T cell and B cell immunodeficiency) and four DOLite terms (osteosarcoma, vascular dementia, adenoma and amyotrophic lateral sclerosis) to be new for the…
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