Eravacycline: From broad-spectrum coverage to novel clinical applications
Abstract
Eravacycline is a novel, fully synthetic fluorocycline antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, aerobic, and anaerobic pathogens, including multidrug-resistant (MDR) strains. It maintains efficacy despite common tetracycline resistance mechanisms, such as efflux pumps and ribosomal protection proteins. Its pharmacokinetic profile is characterized by extensive tissue penetration, particularly into the epithelial lining fluid and alveolar macrophages. Eravacycline is particularly active against MDR pathogens such as carbapenem-resistant Enterobacterales and Acinetobacter baumannii. It also demonstrates efficacy against Achromobacter spp., Burkholderia cepacia complex, Stenotrophomonas maltophilia, and rapidly growing mycobacteria. Moreover, owing to its minimal disruption of the intestinal microbiota, it may help reduce the risk of Clostridioides difficile infection and could serve as an adjunctive therapeutic option in severe or fulminant cases. Phase III trials (IGNITE1 and IGNITE4) demonstrated noninferiority of eravacycline compared with carbapenems in complicated intra-abdominal infections (cIAIs), supporting its approval for this indication. It is generally well tolerated, with adverse effects mainly limited to mild gastrointestinal. Beyond its approved indication for cIAIs, eravacycline shows therapeutic potential in multiple clinical contexts, such as polymicrobial infections from skin and soft tissue (necrotizing fasciitis) or…
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.