The Emerging Role of Metformin in the Treatment of Hepatocellular Carcinoma: Is There Any Value in Repurposing Metformin for HCC Immunotherapy?
Abstract
Simple Summary The study investigates the potential use of metformin, a medication commonly prescribed for type 2 diabetes, in the treatment of hepatocellular carcinoma (HCC). Metformin has been gaining attention for its possible anticancer properties beyond its antidiabetic effects. The study explores the mechanisms through which metformin may exert its anticancer effects, including its impact on metabolic pathways, inflammation reduction and modulation of the tumor microenvironment. It also discusses the potential of combining metformin with immunotherapeutic approaches, such as immune checkpoint inhibitors, to enhance HCC treatment outcomes. While preliminary preclinical studies have shown promising results, further research and clinical trials are needed to determine the optimal dosage, treatment duration and patient selection criteria for metformin-including therapies. In conclusion, repurposing metformin for HCC immunotherapy presents a hopeful avenue for enhancing treatment options. Utilizing metformin’s immunomodulatory properties in combination with other therapeutic strategies could pave the way for more effective and tailored approaches to HCC treatment in the future. Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. There has been significant progress in understanding the risk factors and epidemiology of HCC during the last few decades, resulting in efficient preventative, diagnostic and treatment strategies.…
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