Oxidative Stress and its Relation to Oncogenesis
Abstract
Abstract Reactive oxygen species (ROS) activate multiple functions involved in cell cycle using cell signaling, leading to oxidative stress. The goal of this study was to identify how ROS drives oncogenesis in solid and liquid tumors and identify the essentiality of deregulated genes in different cancers. Through review of literature, 450 genes were identified to be associated with oxidative stress. By overlapping with multiple datasets, 24 genes were found to impact survival in solid and/or liquid tumors, becoming the ROS gene signature. Using PRECOG analysis, high expression of ROS generators was found to lead to poor survival, while low expression of antioxidant genes leads to poor survival. Because ROS genes are associated with poor survival in solid and liquid tumors, this indicates its role in oncogenesis. Expression of mitochondrial complex 1 genes also affect patient survival, as high expression of genes NDUFA9 and NDUFB11 leads to decreased survival in patients irrespective of cancer type. Through the DEPMAP CRISPR database, Complex 1 genes NDUFB9 and NDUFA11 and antioxidant genes PRDX2 and GPX4 were identified to be essential for liquid and solid tumors. ROS genes are essential in many tumors, indicating their vitality in growth and proliferation in cancer. Through DGIDB, COSMIC, and Clue, ROS gene SOD2 was found to be affected by drugs cyclophosphamide and methotrexate. Complex 1 gene NDUFB9 is affected by drugs metformin hydrochloride and NV-128, all known…
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.