Metformin and Its Benefits in Improving Gut Microbiota Disturbances in Diabetes Patients
Abstract
The human gastrointestinal tract presents a vastly population of microorganisms, called the microbiota.The presence of these microorganisms offers many benefits to the host, through a range of physiological functions.However, there is a potential for these mechanisms to be disrupted condition, known as dysbiosis.Recent results are showing important associations between diabetes and the gut microbiota and how the intestinal flora can influence the prognosis of this illness.Microbial intestinal imbalance has been linked to alterations in insulin sensitivity and in glucose metabolism and may play an important role in the development of diabetes.Metformin is one of the most important and widely used first-line medications for the management of type 2 diabetes (T2D).It is a complex drug with multiple sites of action and multiple molecular mechanisms.In recent years, attention has been directed to other modes of action, other than the classic ones, with increasing evidence of a major key role of the intestine.By analysing the effects of metformin on the homeostasis of the microbiota of diabetes patients, our present topic becomes one of the major importance in understanding how metformin therapy can improve gut microbiota dysbiosis and thus provide a better outcome for this illness.
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.