The role of metformin in obesity-driven endometrial cancer
Abstract
Adverse event AEH Atypical endometrial hyperplasia AKT Protein kinase B AMPK AMP-activated kinase ANCOVA Analysis of covariance BD From b.i.d bis in die or twice daily BMI Body mass index CA-9 Carbonic anhydrase 9 cc3 Cleaved caspase-3 CI Combination index COSMIC Catalogue of Somatic Mutations in Cancer CONSORT Consolidated Standards of Reporting Trials CRF Clinical record form DMSO Dimethyl sulfoxide DNA Deoxyribonucleic acid EC Endometrial cancer EEF Endometrioid endometrial adenocarcinoma eGFR Estimated glomerular filtration rate ELISA Enzyme-linked immunoabsorbent assay ER Oestrogen Receptor FACS Fluorescence-activated cell sorting FFPE Formalin-fixed paraffin-embedded FIGO International Federation of Gynaecology and Obstetrics HEC Hyperinsulinaemic-euglycaemic clamp HIF-1α Hypoxia inducible factor-1 alpha HIER HIER: Heat-induced epitope retrieval Hi-FBS Hi-FBS: Heat-inactived fetal bovine serum HOMA-IR Homeostatic model assessment of insulin resistance HR Hazard Ratio HS Hot-spot hsCRP hsCRP: High-sensitivity CRP ICC Intraclass correlation coefficient IE Invasive edge IGFBP IGFBP: Insulin-like growth factor binding protein IHC Immunohistochemistry IR Insulin receptor : IR IGF-1 Insulin-like growth factor 1 : IGF1 IGF1R Insulin-like growth factor 1 receptor : IGF1R LVSI Lymphovascular space invasion mAB mAB: Monoclonal antibody MALDI-TOF Matrix-assisted laser desorption/ionization-Time of Flight (Mass spectrometry) MW Molecular weight OCT-1 Organic cation transporter 1…
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