Formulation, Evaluation and Optimization of Metformin Hydrochloride Tablet IP 500mg
Abstract
INTRODUCTION:Oral drug delivery is the fastest and more preferred route for
the drug administration is also the largest and oldest segment of the total drug delivery
market. Various types of drug delivery systems are available to get better therapeutic action
of drug, out of which immediate release drug delivery system is gaining more importance
because of their wide advantages over others like ease of administration , convenience and
noninvasiveness.(1)
Metformin was discovered in 1922.Study in humans began in
1950s by French physician Jean Sterne. It was introduced in France in 1957 and the United
States in 1995.It is on the World Health Organization's List of Essential Medicines, the most
important medications needed in a basic health system. Metformin is believed to be the most
widely used medication for diabetes which is taken by mouth (2) .Metformin hydrochloride
(MH) is an oral hypoglycemic drug that has been used for the management of the noninsulin-
dependent diabetes mellitus. It is taken in tablets of 500 and 850mg, with low and the
incomplete absorption by the gastrointestinal tract, the usual dose being 2g/day and the
maximum dose 3g/day.AIM OF STUDY:Development and evaluation of Metformine hydrochloride IP
500mg tablets by using nine optimized formulations.OBJECTIVE OF STUDY:Carrying out literature survey of the drug molecules , Formulation of the tablets using different trails, Analyzing the trial samples, Optimizing the final formula SUMMARY AND…
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