Simultaneous Estimation of Repaglinide and Metformin Hydrochloride in Tablet Dosage form by Reverse Phase High Performance Liquid Chromatography
Abstract
The present study is the pharmaceutical formulations have gained a lot of importance in today’s world due to greater patient acceptability, increased potency, multiple action, fewer side effects and quick action. Simultaneous analysis procedures are now being used more frequently for analysis of drugs in pharmaceutical formulations due to their advantages i.e. less time consuming, economical, accurate and precise. The aim is development and validation of Metformin Hydrochloride (250mg) and Repaglinide (1mg) using parameters such precision, accuracy, linearity, specificity, robustness, ruggedness. Standard analytical procedure for newer drugs of formulation may not be available in pharmacopoeias; hence it is essential to develop newer analytical methods which are simple, accurate, precise, specific, economic, linear and rapid. From the literature review it was found that a very few analytical methods have been reported for the simultaneous estimation of metformin hydrochloride and repaglinide by RP-HPLC. Therefore in the proposed project, a successful attempt has been made to develop simple, accurate, economic and rapid methods for the estimation of tablet formulation and to validate the methods, as a result three simple, economic, precise and accurate methods were developed and validated by Reverse Phase High performance Liquid Chromatography The method has been validated as per the guidelines given by ICH requirements to assure that the method consistently meets the…
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