The Effect of Genetic Polymorphism on Therapeutic Response of Metformin in Women with Polycystic Ovarian Syndrome in Iraqi Population. (c2020)
Abstract
Insulin resistance and compensatory hyperinsulinemia have been proposed as potential mechanisms for the gonadotropin secretory abnormalities characteristic of PCOS. Thus, metformin, an insulin-lowering agents, has been prescribed extensively to regulate insulin level of patients with PCOS. However, there are individual differences in the treatment effectiveness of metformin among PCOS patients. The exact mechanism of insulin resistance remains to be clarified; however, it is supposed that it originates from the post-receptor defects. The insulin receptor substrate-1 (IRS1) is an important intermediate in insulin signaling pathway. Polymorphisms in IRS1 have been associated with insulin resistance. Respectively, in this study, we investigated the effect of the polymorphisms of IRS1 on the treatment effectiveness of metformin in PCOS patients. The study involved 100 women diagnosed with PCOS according to Rotterdam criteria and 100 control healthy women. All patients diagnosed with PCOS received 500 mg twice daily for 12 weeks. Both case and control group were genotyped for the single nucleotide polymorphisms (SNPs) (rs1801123) of IRS.1.Main outcome measures were hormonal parameters, metabolic parameters, and lipid panel parameters. They were measured at baseline for control and PCOS group and 12 weeks post metformin treatment for PCOS patients only.Our study has shown that metformin had differential effects on fasting insulin level, HbA1C, LH, LH/FSH ratio, testosterone…
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.