A Rapid RP-HPLC Method Development and Validation for the Simultaneous Estimation of Alogliptin Benzoate and Metformin Hcl In Bulk and Pharmaceutical Dosage form
Abstract
Pharmaceutical chemistry deals with the chemistry of substances used as a therapeutic agent in medicine. It embraces the main branches of chemistry, radiochemistry analytical, physical, and organic chemistry. Its scope expands with development, in medicinal and allied studies, and the emphasis shifts as knowledge advances. On the other hand it is more narrowly concerned with isolation, determination of structure and synthesis of compounds (mainly organic), which may be used in medicine. It also involves the study of metabolism, mechanism of action of drugs and relationship between structure and biological activity. The developed RP-HPLC method was specific, simple, sensitive, precise, accurate and robust, for the detection of Metformin HCL and Alogliptin benzoate in pure and pharmaceutical dosage form. The proposed method is quite simple and do not require any pretreatment of the drug and tedious extraction procedure. The method has a wider linear dynamic range with good accuracy and precision. So the proposed method is used for the routine analysis of Metformin HCL and Alogliptin benzoate in pharmaceutical quality control.
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