Molecular impact of metformin on hepatocellular metabolism
Abstract
This study aimed to extent our understanding of the hepatocellular metformin transport and cellular mode of action. A LC-MS/MS based metformin quantification method and a cell number quantification method for the normalization of metabolomics data were developed. The uptake of metformin by Hep G2 cells was assessed and the impact of glucose and metformin on the metabolism was analyzed in a diabetes and cancer related context.
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