The Effect of Diet, Exercise and Metformin on the Progression of Prostate Cancer
Abstract
Prior research has suggested that life style factors, such as diet and physical activity, influence\nprostate cancer (PCa) progression. Metformin intake has been shown to be associated with\ndecreased cancer risk in type II diabetic patients. We hypothesize that a low carbohydrate diet,\nprolonged aerobic exercise and metformin treatment can all independently slow prostate tumor\ndevelopment and a combination regimen will have an additive benefit. We used LNCaP\nxenografts to test this hypothesis. Results revealed that a diet low in carbohydrate reduced food\nconsumption and a combination with exercise significantly reduced animal body weights. Ten\nweeks of metformin did not significantly alter tumor growth rate compared to control animals.\nTen weeks of exercise significantly inhibited tumor growth. Out results suggest that dietary\ncarbohydrate alteration or the administration of metformin alone cannot significantly influence\nprostate tumor progression. A suitable sustained exercise regimen may offer a more protective\neffect against PCa progression.
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