Topical metformin 30 % gel in the treatment of acne vulgaris: A split face, placebo controlled study
Abstract
Patients and methods: This split face study was designed to evaluate the efficacy and safety of 12 weeks application of daily topical metformin in comparison to placebo in the treatment of 21 adolescent female patients suffering from acne vulgaris.Patients were assessed and lesions (comedones, papules, pustules and nodules) were counted at weeks 0,4,8,12,16Week 12 (end of the treatment): the number of comedones, papules and nodules (but not pustules) decreased significantly on the metformin side compared to the placebo side
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