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Olanzapine-Induced Weight Gain: Can Akkermansia Muciniphila Help?

Oliver Freudenreich

2024

Abstract

Akkermansia muciniphila, a gut bacterium, may play a role in managing olanzapine-induced weight gain by maintaining a healthy gut barrier and increasing GLP-1 production. Metformin, often used with olanzapine to manage metabolic issues, may work in part by increasing Akkermansia levels in the gut microbiome. While Akkermansia supplements are available, more research is needed to determine their efficacy and safety compared to established interventions like metformin for antipsychotic-induced weight gain.

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