Antidepressant Use During Pregnancy and the Risk for Gestational Diabetes: A Systematic Review and Meta-Analysis
Abstract
Studies reviewed herein suggest that antidepressants may cause diabetes. Insulin resistance is associated with treatment resistance; overcoming it with metformin improved depression scores in 1 randomized trial in bipolar depression. Quantifying antidepressant-associated gestational diabetes is one way to further examine causation, but even with large numbers, certainty is hard to establish.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.