Antipsychotic-Induced Weight Gain: Prevention and Management
Abstract
Olanzapine and clozapine have the highest metabolic risk. Switching to aripiprazole or ziprasidone may help if clinically appropriate. Consider metformin early (500 mg/day, increase weekly to 2000 mg/day) when weight gain occurs. Avoid in alcoholism and renal failure. GLP-1 receptor agonists may become important treatment options for antipsychotic-induced weight gain.
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