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Antipsychotic-Induced Weight Gain: Best Management Strategies

Scott R. Beach

2025

Abstract

Metformin 750 mg daily combined with lifestyle modifications appears most effective for antipsychotic-induced weight gain. Lower doses may work better than higher doses. Weight gain increases antipsychotic discontinuation risk up to 13 times. Early intervention and regular monitoring of weight changes is crucial. Liraglutide might be more effective when started concurrently with antipsychotics, rather than after weight gain has occurred. Consider preventive strategies.

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