Time to exercise! Boosting exercise performance via AMPK signaling
Abstract
Body physiology follows the daily rhythm driven by the circadian system, which underlies the emerging concept of chrono-medicine. In this issue, Chen et al.1 report that feeding timing modulates adipocyte AMP-activated protein kinase (AMPK) α2 signaling to enhance exercise performance in mice, paving the way for chronotherapeutic approaches of AMPK activators such as metformin.
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