Reduced prevalence of latent TB infection in diabetes patients using metformin and statins
Abstract
Diabetes mellitus increases the risk of tuberculosis (TB) disease and adverse TB outcomes [1]. Emerging evidence suggests diabetes is also associated with latent TB infection (LTBI), and population-based studies reported the prevalence of LTBI among US adults with diabetes to be more than twice that of adults without diabetes (11.6% versus 4.6%) [2, 3]. Given the rapid increase of global diabetes prevalence in regions with high TB burdens, clinical and public health interventions targeting this co-epidemic would avert substantial morbidity and mortality [4]. New data indicate metformin and statin use reduce incidence of active TB, but if they prevent TB infection (LTBI) is unknown. We used national data to report LTBI prevalence was highest among participants with diabetes who did not use statins or metformin. http://ow.ly/W21v30nehnt
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