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Metformin Might Inhibit Virus through Increasing Insulin Sensitivity

Yong Chen, Feng Gu, J. Guan

Chinese Medical Journal, 2018

30 citations

Abstract

To the Editor: Metformin is believed to be the most widely used medication for diabetes as well as the first‐line medication for the treatment of type 2 diabetes, especially in patients who are overweight. Metformin is described as a magic medicine currently due to its broad range of potential benefits for polycystic ovary syndrome, cardiovascular disease, and various cancers and even prolonged lifespan. Recently, limited in vitro and in vivo research suggests that metformin may have inhibitory effect on virus, especially hepatitis C virus (HCV). Besides, it would be amazing if metformin possess antivirus function in hepatitis B virus (HBV), human immunodeficiency virus (HIV), etc., to benefits virus‐infected patients from other aspects of mechanism.

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