SGLT-2 Inhibitors - A Systematic Review of their Extra-Glycaemic Benefits and Safety Profile
Abstract
BACKGROUND Type 2 Diabetes mellitus is a major cause of mortality due to its complications such as cardiovascular disease (CVD), stroke and end stage renal disease (ESRD). Sodium Glucose Co-Transporter-2 inhibitors is a new class of oral hypoglycaemics which impart additional benefits primarily on heart and kidney. The most commonly used drugs in this class include Canagliflozin, Dapagliflozin and Empagliflozin. However, these drugs are associated with certain adverse effects. This review aims to appraise the extra-glycaemic benefits and adverse effect profile of SGLT-2 inhibitors so as to minimize the morbidity and mortality associated with type 2 diabetes mellitus. METHODS Thorough literature search was made using search engines like PubMed, Cochrane library, Medline and Google scholar to retrieve articles pertaining to extra glycaemic benefits and adverse effects of SGLT2i. RESULTS Majority of studies like CANVAS, EMPA-REG and DECLARE-TIMI done on Canagliflozin, Empagliflozin and Dapagliflozin respectively have concluded that these drugs possess additional benefits like reduced risk of heart failure, positive effects on kidney functions, favourable effects on body weight, reduced levels of uric acid and reduction in blood pressure. However, these drugs are associated with certain adverse effects like increased risk of genital and urinary tract infection. CONCLUSIONS The extra-glycaemic benefits of SGLT2i on heart, kidney and other parameters like body weight, uric acid…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Risk Factors for Coronavirus Disease 2019 (COVID-19) Death in a Population Cohort Study from the Western Cape Province, South Africa
- Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis
- A methodology for assessing deployment trauma and its consequences in OEF/OIF/OND veterans: The TRACTS longitudinal prospective cohort study
- Post‑COVID‑19 Syndrome in Outpatients: a Cohort Study
- Factors Influencing Primary and Secondary Implant Stability—A Retrospective Cohort Study with 582 Implants in 272 Patients
- Electroacupuncture for Painful Diabetic Peripheral Neuropathy: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.